Medical University of Vienna
Center for Physiology and Pharmacology
Institute for Vascular Biology and Thrombosis Research
Schwarzspanierstrasse 17
1090 Vienna
omar.sharif@meduniwien.ac.at
Sharif Lab
Vogel A, Martin K, Soukup K, Halfmann A, Kerndl M, Brunner JS, Hofmann M, Oberbichler L, Korosec A, Kuttke M, Datler H, Kieler M, Musiejovsky L, Dohnal A*, Sharif O*, Schabbauer G*(2022). JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1 mediated regulatory T cell induction. Cell Reports Feb 22;38(8):110420; https://doi.org/10.1016/j.celrep.2022.110420
Sharif O, Brunner JS, Korosec A, Martins R, Jais A, Snijder B, Vogel A, Caldera M, Hladik A, Lakovits K, Saluzzo S, Boehm B, Gorki AD, Mesteri I, Lindroos JC, Tillmann K, Stoiber D, Menche J, Schabbauer G, Bilban M, Superti-Furga G, Esterbauer H, Knapp S (2021). Beneficial Metabolic Effects of TREM2 in Obesity are Uncoupled from its Expression on Macrophages. Diabetes Feb 24. https://doi.org/10.2337/db20-0572
Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O*, Schabbauer G* (2020). The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages. Nature Metabolism Dec;2(12):1427-1442. https://doi.org/10.1038/s42255-020-00311-5
Esparza-Baquer A, Labiano I, Sharif O, Agirre AL 1, Oakley F, Rodrigues PM, Zhuravleva E, O'Rourke CJ, Hijona E, Agüero RJ, Riaño I, Landa A, Casta AL, Zaki MYW, Munoz-Garrido P, Azkargorta M, Elortza F, Vogel A, Schabbauer G, Aspichueta P, Andersen JB, Knapp S, Mann DA, Bujanda L, Banales JM, Perugorria MJ (2020). TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms. Gut Sep 9;gutjnl-2019-319227. https://doi.org/10.1136/gutjnl-2019-319227
Perugorria MJ, Esparza-Baquer A, Oakley F, Labiano I, Korosec A, Jais A, Mann J, Tiniakos D, Santos-Laso A, Arbelaiz A, Gawish R, Sampedro A, Fontanellas A, Hijona E, Jiménez-Agüero R, Esterbauer H, Stoiber D, Bujanda L, Banales JM, Knapp S, Sharif O*, Mann DA* (2018) Non-Parenchymal TREM-2 protects the Liver from Immune-mediated Hepatocellular damage. Gut Jan 27. https://doi.org/10.1136/gutjnl-2017-314107
Jais A, Einwallner E, Sharif O, Gossens K, Lu TT, Soyal SM, Medgyesi D, Neureiter D, Paier-Pourani J, Dalgaard K, Duvigneau JC, Lindroos J, Zapf T, Amann S, Saluzzo S, Jantscher F, Stiedl P, Todoric J, Martins R, Oberkofler H, Müller S, Hauser-Kronberger C, Kenner L, Casanova E, Sutterlüty-Fall H, Bilban M, Miller K, Kozlov A, Krempler F, Knapp S, Lumeng CN, Patsch W, Wagner O, Pospisilik AJ, Esterbauer H (2014). Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man. Cell Jul 3;158(1):25-40. https://doi.org/10.1016/j.cell.2014.04.043
Sharif O, Gawish R, Warszawska JM, Martins R, Lakovits K, Hladik A, Doninger B, Brunner J, Korosec A, Schwarzenbacher EJ, Berg T, Kralovics R, Colinge J, Mesteri I, Gilfillan S, Salmaggi A, Verschoor A, Colonna M, Knapp S (2014). The Triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia. Plos Pathogens Jun 12;10(6) e1004167. https://doi.org/10.1371/journal.ppat.1004167
Matt U*, Sharif O*, Martins R, Furtner T, Langeberg L, Gawish R, Elbau I, Zivkovic A, Lakovits K, Oskolkova O, Doninger B, Vychytil A, Perkmann T, Schabbauer G, Binder CJ, Bochkov VN, Scott JD, Knapp S. (2013). WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs. J Clin Invest 123(7):3014-24. https://doi.org/10.1172/JCI60681
Sharif O, Matt U, Saluzzo S, Lakovits K, Haslinger I, Furtner T, Doninger B, Knapp S (2013). The scavenger receptor CD36 downmodulates the early inflammatory response while enhancing bacterial phagocytosis during pneumococcal pneumonia. J Immunol 190(11):5640-8. https://doi.org/10.4049/jimmunol.1202270
Baumann CL*, Aspalter IM*, Sharif O*, Pichlmair A, Blüml S, Grebien F, Bruckner M, Pasierbek P, Aumayr K, Planyavsky M, Bennett KL, Colinge J, Knapp S#, Superti-Furga G (2010). CD14 is a coreceptor of Toll-like receptors 7 and 9. J Exp Med. 207(12):2689-701. https://doi.org/10.1084/jem.20101111