Macrophage-stellate metabolic cross-talk in hepatic fibrosis


Omar Sharif

Medical University of Vienna
Center for Physiology and Pharmacology
Institute for Vascular Biology and Thrombosis Research
Schwarzspanierstrasse 17
1090 Vienna

omar.sharif@meduniwien.ac.at
Sharif Lab


Research Publications

Vogel A, Martin K, Soukup K, Halfmann A, Kerndl M, Brunner JS, Hofmann M, Oberbichler L, Korosec A, Kuttke M, Datler H, Kieler M, Musiejovsky L, Dohnal A*, Sharif O*, Schabbauer G*(2022). JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1 mediated regulatory T cell induction. Cell Reports Feb 22;38(8):110420; https://doi.org/10.1016/j.celrep.2022.110420

 

Sharif O, Brunner JS, Korosec A, Martins R, Jais A, Snijder B, Vogel A, Caldera M, Hladik A, Lakovits K, Saluzzo S, Boehm B, Gorki AD, Mesteri I, Lindroos JC, Tillmann K, Stoiber D, Menche J, Schabbauer G, Bilban M, Superti-Furga G, Esterbauer H, Knapp S (2021). Beneficial Metabolic Effects of TREM2 in Obesity are Uncoupled from its Expression on Macrophages. Diabetes Feb 24. https://doi.org/10.2337/db20-0572

 

Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O*, Schabbauer G* (2020). The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages. Nature Metabolism Dec;2(12):1427-1442. https://doi.org/10.1038/s42255-020-00311-5

 

 Esparza-Baquer A, Labiano I, Sharif O, Agirre AL 1, Oakley F, Rodrigues PM, Zhuravleva E, O'Rourke CJ, Hijona E, Agüero RJ, Riaño I, Landa A, Casta AL, Zaki MYW, Munoz-Garrido P, Azkargorta M, Elortza F, Vogel A, Schabbauer G, Aspichueta P, Andersen JB, Knapp S, Mann DA, Bujanda L, Banales JM, Perugorria MJ (2020). TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms. Gut Sep 9;gutjnl-2019-319227. https://doi.org/10.1136/gutjnl-2019-319227

 

Perugorria MJ, Esparza-Baquer A, Oakley F, Labiano I, Korosec A, Jais A, Mann J, Tiniakos D, Santos-Laso A, Arbelaiz A, Gawish R, Sampedro A, Fontanellas A, Hijona E, Jiménez-Agüero R, Esterbauer H, Stoiber D, Bujanda L, Banales JM, Knapp S, Sharif O*, Mann DA* (2018) Non-Parenchymal TREM-2 protects the Liver from Immune-mediated Hepatocellular damage. Gut Jan 27. https://doi.org/10.1136/gutjnl-2017-314107

 

Jais A, Einwallner E, Sharif O, Gossens K, Lu TT, Soyal SM, Medgyesi D, Neureiter D, Paier-Pourani J, Dalgaard K, Duvigneau JC, Lindroos J, Zapf T, Amann S, Saluzzo S, Jantscher F, Stiedl P, Todoric J, Martins R, Oberkofler H, Müller S, Hauser-Kronberger C, Kenner L, Casanova E, Sutterlüty-Fall H, Bilban M, Miller K, Kozlov A, Krempler F, Knapp S, Lumeng CN, Patsch W, Wagner O, Pospisilik AJ, Esterbauer H (2014). Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man. Cell Jul 3;158(1):25-40. https://doi.org/10.1016/j.cell.2014.04.043

 

Sharif O, Gawish R, Warszawska JM, Martins R, Lakovits K, Hladik A, Doninger B, Brunner J, Korosec A, Schwarzenbacher EJ, Berg T, Kralovics R, Colinge J, Mesteri I, Gilfillan S, Salmaggi A, Verschoor A, Colonna M, Knapp S (2014). The Triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia. Plos Pathogens Jun 12;10(6) e1004167. https://doi.org/10.1371/journal.ppat.1004167

 

Matt U*, Sharif O*, Martins R, Furtner T, Langeberg L, Gawish R, Elbau I, Zivkovic A, Lakovits K, Oskolkova O, Doninger B, Vychytil A, Perkmann T, Schabbauer G, Binder CJ, Bochkov VN, Scott JD, Knapp S. (2013). WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs. J Clin Invest 123(7):3014-24. https://doi.org/10.1172/JCI60681

 

Sharif O, Matt U, Saluzzo S, Lakovits K, Haslinger I, Furtner T, Doninger B, Knapp S (2013). The scavenger receptor CD36 downmodulates the early inflammatory response while enhancing bacterial phagocytosis during pneumococcal pneumonia. J Immunol 190(11):5640-8. https://doi.org/10.4049/jimmunol.1202270

 

Baumann CL*, Aspalter IM*, Sharif O*, Pichlmair A, Blüml S, Grebien F, Bruckner M, Pasierbek P, Aumayr K, Planyavsky M, Bennett KL, Colinge J, Knapp S#, Superti-Furga G (2010). CD14 is a coreceptor of Toll-like receptors 7 and 9. J Exp Med. 207(12):2689-701. https://doi.org/10.1084/jem.20101111

A Special Research Program funded by the Austrian Science Fund 2021-2029

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